TTC39C

Across TCGA pan-cancer cohorts, TTC39C mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated TTC39C data layer compared with 26 for mass-spec protein and 7 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher TTC39C mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated TTC39C expression acts as an unfavorable survival marker, although some lineages such as PDAC and LSCC show a favorable association.

CCRCC, PDAC, and LSCC are the cancer types where TTC39C mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Tertile	III,IV	0.198	0.887	.024	8	view →
PDAC	DFS	Median	III,IV	0.469	0.230	.012	4	view →
LSCC	OS	Quartile	All	0.918	0.722	.020	4	view →
GBM	OS	Tertile	All	0.297	0.472	.049	2	view →
LUAD	OS	Median	II,III,IV	0.517	0.761	.047	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

TTC39C–CCRCC (DFS)

Open the CCRCC breakdown →