TTC33

Across TCGA patient cohorts, TTC33 mutation is significantly associated with the total protein of many other genes, with 6 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TTC33-associated genes across cancer lineages are S6_pS240_S244, STAT3_pY705, and MEK1. Each is linked with TTC33 in more than 1 cancer types. Because this analysis shows association rather than direction, both TTC33-to-partner and partner-to-TTC33 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, S6_pS240_S244 grouped by TTC33-low versus TTC33-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TTC33→partner) and Y-score (partner→TTC33) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	S6_pS240_S244 →	+0.523	+2.321	.010	.035	3	1
UCEC	STAT3_pY705 →	-0.295	-2.321	.025	.035	3	1
UCEC	MEK1 →	+0.482	+2.321	.008	.035	2	1
UCEC	VHL →	-0.915	-3.169	.007	.019	2	1
UCEC	Caspase-7-cleavedD198 →	+0.723	+3.459	.015	.005	1	2
UCEC	p62 Lck ligand →	+0.569	+2.321	<.001	.035	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

S6_pS240_S244 by TTC33 expression — UCEC

Explore this box plot interactively →