TTC33

Across TCGA pan-cancer cohorts, TTC33 RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated TTC33 data layer compared with 2 for mutation status and 6 for mass-spec protein.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher TTC33 RNA is associated with better overall survival. In most high-consensus cancer types, elevated TTC33 expression acts as an unfavorable survival marker, although some lineages such as KIRC and MESO show a favorable association.

KIRC, LIHC, and MESO are the cancer types where TTC33 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	OS	Median	All	0.744	0.516	<.001	119	view →
LIHC	DFS	Tertile	All	0.418	0.618	<.001	35	view →
MESO	OS	Median	All	0.731	0.292	.002	26	view →
UVM	DFS	Quartile	III,IV	0.222	0.903	.001	25	view →
THCA	OS	Median	All	0.983	0.997	.006	24	view →
CESC	DFS	Quartile	III,IV	0.241	0.818	.007	20	view →
LUSC	DFS	Tertile	All	0.874	0.607	.003	20	view →
THYM	DFS	Tertile	II,III,IV	1.000	0.568	.009	16	view →
SKCM	OS	Quartile	III,IV	0.512	0.261	.005	15	view →
LGG	DFS	Median	All	0.869	0.779	.015	10	view →
LUAD	DFS	Tertile	All	0.838	0.687	.006	9	view →
READ	OS	Median	IV	0.966	0.651	.023	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

TTC33–KIRC (OS)

Open the KIRC breakdown →