TTC33

Across TCGA cell cohorts, TTC33 mutation is significantly associated with the RNA expression of many other genes, with 10 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TTC33-associated genes across cancer lineages are BIRC8, RETNLB, and USP26. Each is linked with TTC33 in more than 1 cancer types. Because this analysis shows association rather than direction, both TTC33-to-partner and partner-to-TTC33 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, BIRC8 grouped by TTC33-low versus TTC33-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TTC33→partner) and Y-score (partner→TTC33) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	BIRC8 →	+0.016	+4.977	<.001	.007	3	1
SKIN	RETNLB →	+0.041	+4.977	<.001	.007	3	1
LARGE_INTESTINE	USP26 →	+0.067	+3.836	<.001	.003	3	1
LARGE_INTESTINE	TLX3 →	+0.502	+3.845	<.001	.003	3	1
LARGE_INTESTINE	BPIFB6 →	+0.016	+4.022	<.001	.006	3	1
LARGE_INTESTINE	PYDC1 →	+0.177	+3.347	.006	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

BIRC8 by TTC33 expression — SKIN

Explore this box plot interactively →