TTC31

Across TCGA patient cohorts, TTC31 mutation is significantly associated with the RNA expression of many other genes, with 1,244 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TTC31-associated genes across cancer lineages are SNRPD3, MTFMT, and SIGLEC8. Each is linked with TTC31 in more than 1 cancer types. Because this analysis shows association rather than direction, both TTC31-to-partner and partner-to-TTC31 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SNRPD3 grouped by TTC31-low versus TTC31-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TTC31→partner) and Y-score (partner→TTC31) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	SNRPD3 →	+0.340	+2.831	.006	.001	3	2
UCEC	MTFMT →	+0.412	+2.502	.001	.002	3	2
UCEC	SIGLEC8 →	+0.511	+3.637	<.001	.001	3	2
UCEC	GTF2H1 →	+0.452	+3.169	.001	<.001	3	2
UCEC	GPN3 →	+0.491	+2.839	.005	.001	3	2
UCEC	VPS29 →	+0.513	+3.016	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,244 associations by consensus.

SNRPD3 by TTC31 expression — UCEC

Explore this box plot interactively →