TTC31

Across TCGA pan-cancer cohorts, TTC31 RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of TTC31’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where TTC31 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types TTC31 is over-expressed in tumor, although a few such as KICH show the opposite, repressed pattern.

HNSC, KIRC, and KIRP are the cancer types where TTC31 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TTC31 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Female	III,IV	+1.064	<.001	12	view →
KIRC	Female	All	+0.906	<.001	12	view →
KIRP	All	II,III,IV	+0.858	<.001	9	view →
LIHC	All	II,III,IV	+0.599	<.001	8	view →
BLCA	All	All	+0.524	<.001	8	view →
STAD	All	II,III,IV	+0.666	<.001	6	view →
BRCA	All	II,III,IV	+0.238	<.001	6	view →
KICH	Female	All	−1.091	<.001	5	view →
CHOL	All	All	+0.890	<.001	5	view →
LUSC	Male	All	+0.425	<.001	4	view →
ESCA	All	II,III,IV	+0.845	.004	3	view →
COAD	Male	II,III,IV	+0.296	.023	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

TTC31–HNSC

Open the HNSC breakdown →