TTC29

Across TCGA patient cohorts, TTC29 mutation is significantly associated with the total protein of many other genes, with 31 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TTC29-associated genes across cancer lineages are Heregulin, Acetyl-a-Tubulin-Lys40, and P-Cadherin. Each is linked with TTC29 in more than 1 cancer types. Because this analysis shows association rather than direction, both TTC29-to-partner and partner-to-TTC29 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Heregulin grouped by TTC29-low versus TTC29-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TTC29→partner) and Y-score (partner→TTC29) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Heregulin →	-0.120	-2.222	.016	.010	3	2
UCEC	Acetyl-a-Tubulin-Lys40 →	+0.442	+2.594	.030	.006	3	2
UCEC	P-Cadherin →	-0.135	-2.321	.019	.033	3	2
UCEC	Shc_pY317 →	-0.156	-2.222	.010	.010	3	2
UCEC	ASNS →	+0.436	+1.906	.002	.016	3	2
UCEC	EGFR_pY1068 →	-0.251	-3.584	.013	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 31 associations by consensus.

Heregulin by TTC29 expression — UCEC

Explore this box plot interactively →