TTC26

Across TCGA pan-cancer cohorts, TTC26 RNA is linked to patient survival in 28 of 34 cancer types, making it the most broadly survival-associated TTC26 data layer compared with 2 for mutation status and 6 for mass-spec protein.

The strongest signal is observed in kidney chromophobe (KICH), where higher TTC26 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated TTC26 expression acts as an unfavorable survival marker, although some lineages such as KIRC and UCS show a favorable association.

KICH, LIHC, and KIRC are the cancer types where TTC26 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KICH	OS	Median	All	0.718	1.000	<.001	84	view →
LIHC	OS	Median	All	0.587	0.782	<.001	66	view →
KIRC	DFS	Tertile	All	0.760	0.501	.001	65	view →
LGG	DFS	Median	All	0.616	0.859	<.001	54	view →
UCS	OS	Tertile	IV	1.000	0.206	.024	30	view →
ACC	DFS	Median	All	0.566	0.903	<.001	30	view →
READ	OS	Median	III,IV	0.706	0.301	.001	26	view →
MESO	DFS	Quartile	II,III,IV	0.270	0.545	.008	25	view →
BRCA	OS	Median	IV	0.638	0.172	.004	25	view →
LAML	DFS	Median	All	0.465	0.271	.013	22	view →
LUSC	DFS	Quartile	III,IV	0.141	0.897	.001	21	view →
CESC	DFS	Quartile	All	0.754	0.914	.001	20	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 28 lineages.

TTC26–KICH (OS)

Open the KICH breakdown →