Across TCGA patient cohorts, TTC23L mutation is significantly associated with the total protein of many other genes, with 37 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TTC23L-associated genes across cancer lineages are EGFR_pY1068, MEK1, and 4E-BP1. Each is linked with TTC23L in more than 1 cancer types. Because this analysis shows association rather than direction, both TTC23L-to-partner and partner-to-TTC23L results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TTC23L→partner) and Y-score (partner→TTC23L) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.245	-2.700	.004	.005	3	2
UCEC	MEK1 →	+0.274	+2.087	.027	.005	3	2
COAD	4E-BP1 →	+0.313	+3.008	.005	.019	3	2
UCEC	Di-Ras3 →	-0.199	-3.893	<.001	<.001	3	2
COAD	Lck →	+0.313	+3.025	.048	.019	3	2
UCEC	14-3-3_beta →	-0.113	-2.780	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 37 associations by consensus.

Exploration

TTC23L survival (RNA) · tumor vs normal (RNA) · all TTC23L data types