Across TCGA pan-cancer cohorts, TTC23L RNA differs between tumor and matched normal tissue in 6 of 18 cancer types tested, making tumor–normal expression one of TTC23L’s most consistent transcriptional readouts.
The strongest signal is observed in kidney chromophobe (KICH), where TTC23L RNA is repressed in tumor relative to normal tissue. In most cancer types TTC23L is over-expressed in tumor, although a few such as KICH and THCA show the opposite, repressed pattern.
KICH, THCA, and LIHC are the cancer types where TTC23L tumor–normal differential expression is most reproducible.
RNA tumor vs normal associations by lineage
Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TTC23L RNA (log2); positive values indicate higher expression in tumor. p-values are from the differential-expression test.