TTC23

Across TCGA cell cohorts, TTC23 mutation is significantly associated with the RNA expression of many other genes, with 7 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TTC23-associated genes across cancer lineages are USP17L13, USP17L17, and AVP. Each is linked with TTC23 in more than 1 cancer types. Because this analysis shows association rather than direction, both TTC23-to-partner and partner-to-TTC23 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, USP17L13 grouped by TTC23-low versus TTC23-high in LUNG_SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TTC23→partner) and Y-score (partner→TTC23) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	USP17L13 →	+0.013	+5.029	<.001	.006	3	1
LUNG_SCLC	USP17L17 →	+0.013	+5.029	<.001	.006	3	1
LARGE_INTESTINE	AVP →	+0.048	+3.217	<.001	.006	3	1
LARGE_INTESTINE	DEUP1 →	+0.354	+3.569	<.001	.006	3	1
LARGE_INTESTINE	OR10A4 →	+0.045	+2.938	.007	.007	3	1
LARGE_INTESTINE	FAM153B →	+0.557	+3.618	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

USP17L13 by TTC23 expression — LUNG_SCLC

Explore this box plot interactively →