TTC17

Across TCGA patient cohorts, TTC17 mutation is significantly associated with the total protein of many other genes, with 50 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TTC17-associated genes across cancer lineages are mTOR_pS2448, PAI-1, and GAPDH. Each is linked with TTC17 in more than 2 cancer types. Because this analysis shows association rather than direction, both TTC17-to-partner and partner-to-TTC17 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, mTOR_pS2448 grouped by TTC17-low versus TTC17-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TTC17→partner) and Y-score (partner→TTC17) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	mTOR_pS2448 →	-0.129	-2.234	.001	.001	3	3
UCEC	PAI-1 →	+0.277	+1.321	.003	.005	3	3
UCEC	GAPDH →	+0.308	+1.415	.039	.040	3	2
UCEC	PDCD4 →	-0.565	-2.807	<.001	<.001	3	2
UCEC	Src_pY527 →	-0.246	-1.678	.040	.019	3	2
UCEC	STAT3_pY705 →	-0.291	-1.736	<.001	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 50 associations by consensus.

mTOR_pS2448 by TTC17 expression — UCEC

Explore this box plot interactively →