TTC17

Across TCGA pan-cancer cohorts, TTC17 RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated TTC17 data layer compared with 4 for mutation status and 4 for mass-spec protein.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher TTC17 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated TTC17 expression acts as an unfavorable survival marker, although some lineages such as UCS and READ show a favorable association.

KIRP, CESC, and KICH are the cancer types where TTC17 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	DFS	Quartile	II,III,IV	0.234	0.781	<.001	63	view →
CESC	DFS	Quartile	III,IV	0.213	0.861	<.001	58	view →
KICH	DFS	Tertile	III,IV	0.283	0.931	.003	52	view →
ACC	DFS	Tertile	All	0.348	0.749	<.001	39	view →
BLCA	DFS	Median	All	0.207	0.440	.008	30	view →
UCS	OS	Median	IV	0.732	0.224	.018	24	view →
READ	OS	Tertile	II,III,IV	0.874	0.313	.004	22	view →
PAAD	OS	Quartile	All	0.606	0.324	.016	20	view →
HNSC	OS	Tertile	All	0.632	0.858	.001	18	view →
LIHC	DFS	Tertile	All	0.455	0.617	.005	18	view →
COAD	DFS	Quartile	All	0.423	0.621	.022	11	view →
BRCA	OS	Quartile	All	0.977	0.942	.011	10	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

TTC17–KIRP (DFS)

Open the KIRP breakdown →