TTC16

Across TCGA cell cohorts, TTC16 mutation is significantly associated with the RNA expression of many other genes, with 284 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TTC16-associated genes across cancer lineages are OR11H6, PRSS54, and GPR101. Each is linked with TTC16 in more than 1 cancer types. Because this analysis shows association rather than direction, both TTC16-to-partner and partner-to-TTC16 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR11H6 grouped by TTC16-low versus TTC16-high in CNS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TTC16→partner) and Y-score (partner→TTC16) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	OR11H6 →	+0.026	+4.321	<.001	.009	3	2
LUNG_SCLC	PRSS54 →	+0.026	+4.169	<.001	.001	3	2
UPPER_AERODIGESTIVE_TRACT	GPR101 →	+0.099	+4.736	<.001	.009	3	2
SKIN	MSGN1 →	+0.045	+4.022	<.001	.006	3	2
CNS	TAS1R2 →	+0.010	+4.643	.003	.003	3	1
CNS	SLC36A3 →	+0.006	+4.643	.002	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 284 associations by consensus.

OR11H6 by TTC16 expression — CNS

Explore this box plot interactively →