TTC16

Across TCGA pan-cancer cohorts, TTC16 RNA is linked to patient survival in 29 of 34 cancer types, making it the most broadly survival-associated TTC16 data layer compared with 6 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher TTC16 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated TTC16 expression acts as an unfavorable survival marker, although some lineages such as HNSC and SKCM show a favorable association.

HNSC, SKCM, and BRCA are the cancer types where TTC16 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	All	0.749	0.643	<.001	87	view →
SKCM	OS	Quartile	All	0.450	0.243	<.001	79	view →
BRCA	DFS	Median	IV	0.795	0.301	<.001	63	view →
CESC	OS	Median	All	0.853	0.739	.008	62	view →
COAD	OS	Quartile	All	0.394	0.748	<.001	60	view →
LGG	DFS	Median	All	0.660	0.806	<.001	51	view →
LUSC	DFS	Quartile	II,III,IV	0.644	0.821	.004	44	view →
LUAD	OS	Quartile	All	0.801	0.607	<.001	43	view →
READ	DFS	Median	IV	0.322	0.862	<.001	43	view →
UCEC	OS	Quartile	All	0.655	0.631	.002	42	view →
SARC	OS	Median	All	0.836	0.649	<.001	40	view →
ACC	DFS	Tertile	III,IV	0.274	0.709	.006	35	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 29 lineages.

TTC16–HNSC (DFS)

Open the HNSC breakdown →