TTC14

Across TCGA cell cohorts, TTC14 mutation is significantly associated with the RNA expression of many other genes, with 227 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TTC14-associated genes across cancer lineages are SUPT20HL1, FBXW10, and FGF6. Each is linked with TTC14 in more than 1 cancer types. Because this analysis shows association rather than direction, both TTC14-to-partner and partner-to-TTC14 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SUPT20HL1 grouped by TTC14-low versus TTC14-high in OVARY.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TTC14→partner) and Y-score (partner→TTC14) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	SUPT20HL1 →	+0.074	+4.222	<.001	.006	3	2
LARGE_INTESTINE	FBXW10 →	+0.203	+3.675	<.001	<.001	3	2
LUNG_NSCLC_LUSC	FGF6 →	+0.032	+4.584	<.001	.001	3	1
LUNG_NSCLC_LUSC	CRYAA2 →	+0.044	+4.108	.001	.005	3	1
SKIN	USP26 →	+0.042	+4.095	<.001	.009	3	1
SKIN	OR52N5 →	+0.078	+4.095	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 227 associations by consensus.

SUPT20HL1 by TTC14 expression — OVARY

Explore this box plot interactively →