TTC13

Across TCGA patient cohorts, TTC13 mutation is significantly associated with the RNA expression of many other genes, with 5,223 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TTC13-associated genes across cancer lineages are MPLKIP, ELP5, and ALMS1-IT1. Each is linked with TTC13 in more than 2 cancer types. Because this analysis shows association rather than direction, both TTC13-to-partner and partner-to-TTC13 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MPLKIP grouped by TTC13-low versus TTC13-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TTC13→partner) and Y-score (partner→TTC13) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MPLKIP →	+0.297	+2.087	.005	.005	3	3
UCEC	ELP5 →	+0.352	+2.224	<.001	<.001	3	3
UCEC	ALMS1-IT1 →	+0.295	+1.947	.001	.002	3	3
UCEC	CRYBB2P1 →	+0.425	+2.871	<.001	<.001	3	3
UCEC	MED31 →	+0.434	+1.986	<.001	<.001	3	3
PRAD	RNY3P4 →	+0.258	+7.939	<.001	.008	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,223 associations by consensus.

MPLKIP by TTC13 expression — UCEC

Explore this box plot interactively →