TTC13

Across TCGA pan-cancer cohorts, TTC13 RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of TTC13’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where TTC13 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types TTC13 is over-expressed in tumor, although a few such as KICH show the opposite, repressed pattern.

HNSC, KIRC, and BLCA are the cancer types where TTC13 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TTC13 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	III,IV	+1.021	<.001	12	view →
KIRC	Female	All	+0.795	<.001	11	view →
BLCA	All	All	+0.841	<.001	10	view →
LIHC	Female	II,III,IV	+1.714	<.001	9	view →
STAD	Male	II,III,IV	+1.047	<.001	8	view →
LUAD	Male	All	+0.691	<.001	7	view →
UCEC	All	II,III,IV	+1.159	<.001	6	view →
KICH	Female	All	−1.064	<.001	6	view →
BRCA	All	II,III,IV	+0.678	<.001	6	view →
CHOL	Male	All	+2.764	<.001	5	view →
KIRP	All	IV	+0.835	.013	4	view →
LUSC	All	All	+0.376	<.001	4	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 15 lineages.

TTC13–HNSC

Open the HNSC breakdown →