TTC12

Across TCGA patient cohorts, TTC12 mutation is significantly associated with the total protein of many other genes, with 53 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TTC12-associated genes across cancer lineages are PKC-delta_pS664, ATM, and EGFR_pY1068. Each is linked with TTC12 in more than 2 cancer types. Because this analysis shows association rather than direction, both TTC12-to-partner and partner-to-TTC12 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PKC-delta_pS664 grouped by TTC12-low versus TTC12-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TTC12→partner) and Y-score (partner→TTC12) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PKC-delta_pS664 →	-0.104	-2.700	.007	.005	3	3
UCEC	ATM →	-0.569	-2.308	<.001	.005	3	3
UCEC	EGFR_pY1068 →	-0.216	-1.362	.007	.034	3	2
UCEC	A-Raf_pS299 →	-0.117	-2.222	.002	.009	3	2
UCEC	MEK1 →	+0.361	+1.925	.002	.004	3	2
UCEC	Notch1 →	+0.130	+1.222	.004	.035	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 53 associations by consensus.

PKC-delta_pS664 by TTC12 expression — UCEC

Explore this box plot interactively →