TTC12

Across TCGA pan-cancer cohorts, TTC12 RNA is linked to patient survival in 20 of 34 cancer types, making it the most broadly survival-associated TTC12 data layer compared with 9 for mutation status and 4 for mass-spec protein.

The strongest signal is observed in rectum adenocarcinoma (READ), where higher TTC12 RNA is associated with better overall survival. In most high-consensus cancer types, elevated TTC12 expression acts as an unfavorable survival marker, although some lineages such as READ and SKCM show a favorable association.

READ, SKCM, and KIRP are the cancer types where TTC12 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
READ	OS	Median	All	0.937	0.433	<.001	103	view →
SKCM	OS	Tertile	II,III,IV	0.487	0.238	<.001	70	view →
KIRP	DFS	Tertile	All	0.928	0.512	.001	67	view →
UCEC	DFS	Tertile	All	0.949	0.862	<.001	58	view →
LGG	DFS	Median	All	0.665	0.801	<.001	50	view →
LIHC	OS	Quartile	All	0.609	0.831	.001	36	view →
KIRC	OS	Median	All	0.739	0.548	<.001	35	view →
UVM	OS	Median	III,IV	0.413	0.836	.016	23	view →
HNSC	OS	Tertile	III,IV	0.396	0.653	.013	19	view →
THYM	DFS	Tertile	III,IV	0.887	0.207	.016	15	view →
MESO	DFS	Tertile	IV	0.321	0.883	.008	12	view →
GBM	OS	Quartile	All	0.216	0.343	.013	11	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 20 lineages.

TTC12–READ (OS)

Open the READ breakdown →