TTC12

Across TCGA cell cohorts, TTC12 mutation is significantly associated with the RNA expression of many other genes, with 16 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TTC12-associated genes across cancer lineages are SLCO1C1, MS4A14, and KRT1. Each is linked with TTC12 in more than 1 cancer types. Because this analysis shows association rather than direction, both TTC12-to-partner and partner-to-TTC12 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SLCO1C1 grouped by TTC12-low versus TTC12-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TTC12→partner) and Y-score (partner→TTC12) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	SLCO1C1 →	+0.439	+3.842	<.001	.001	3	1
LARGE_INTESTINE	MS4A14 →	+0.013	+2.791	<.001	.005	3	1
LARGE_INTESTINE	KRT1 →	+0.450	+3.772	<.001	.002	3	1
LARGE_INTESTINE	NUPR2 →	+0.205	+2.688	.001	.008	3	1
LARGE_INTESTINE	BPIFA1 →	+0.149	+2.688	<.001	.008	3	1
LUNG_SCLC	IL36A →	+0.016	+4.058	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 16 associations by consensus.

SLCO1C1 by TTC12 expression — LARGE_INTESTINE

Explore this box plot interactively →