TTBK1

Across TCGA pan-cancer cohorts, TTBK1 Mutation is linked to patient survival in 11 of 34 cancer types, making it a survival-associated TTBK1 data layer compared with 23 for mass-spec protein and 2 for mass-spec protein.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher TTBK1 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated TTBK1 expression acts as an unfavorable survival marker, although some lineages such as CESC and SKCM show a favorable association.

KIRC, STAD, and LAML are the cancer types where TTBK1 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	OS	Median	All	0.167	0.657	.003	15	view →
STAD	OS	Median	All	0.108	0.544	.003	15	view →
LAML	DFS	Median	All	0.167	0.575	.035	12	view →
BLCA	DFS	Median	III,IV	0.094	0.489	.005	12	view →
PRAD	DFS	Median	All	0.129	0.888	<.001	6	view →
LUAD	OS	Median	All	0.016	0.835	<.001	6	view →
UCEC	OS	Median	IV	0.231	0.592	.036	6	view →
SCLC	DFS	Median	All	0.178	0.573	.019	3	view →
CESC	DFS	Median	All	1.000	0.523	.046	2	view →
ACC	OS	Median	All	0.180	0.632	.033	2	view →
SKCM	DFS	Median	II,III,IV	0.908	0.660	.028	1	view →

Pink = unfavorable, green = favorable. Showing the 11 strongest of 11 lineages.

TTBK1–KIRC (OS)

Open the KIRC breakdown →