TSSK4

Across TCGA patient cohorts, TSSK4 mutation is significantly associated with the total protein of many other genes, with 3 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TSSK4-associated genes across cancer lineages are JNK2, ATM, and ERK2. Each is linked with TSSK4 in more than 1 cancer types. Because this analysis shows association rather than direction, both TSSK4-to-partner and partner-to-TSSK4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, JNK2 grouped by TSSK4-low versus TSSK4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TSSK4→partner) and Y-score (partner→TSSK4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	JNK2 →	+0.244	+3.000	.034	.037	2	1
UCEC	ATM →	-0.628	-3.000	.016	.037	2	1
UCEC	ERK2 →	+0.246	+3.000	.027	.037	1	1

Each partner links to its Q-omics profile. Showing the 3 strongest of 3 associations by consensus.

JNK2 by TSSK4 expression — UCEC

Explore this box plot interactively →