TSSK4

Across TCGA pan-cancer cohorts, TSSK4 RNA is linked to patient survival in 30 of 34 cancer types, making it the most broadly survival-associated TSSK4 data layer compared with 3 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher TSSK4 RNA is associated with better overall survival. In most high-consensus cancer types, elevated TSSK4 expression acts as an unfavorable survival marker, although some lineages such as HNSC and BRCA show a favorable association.

HNSC, BRCA, and SKCM are the cancer types where TSSK4 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	II,III,IV	0.490	0.249	<.001	141	view →
BRCA	OS	Median	III,IV	0.957	0.850	<.001	47	view →
SKCM	OS	Quartile	III,IV	0.516	0.255	.004	47	view →
COAD	DFS	Tertile	All	0.363	0.692	<.001	32	view →
ACC	DFS	Median	All	0.533	0.782	.003	25	view →
LUAD	OS	Median	III,IV	0.779	0.531	.005	25	view →
UCEC	OS	Quartile	IV	0.640	0.278	.014	24	view →
CESC	DFS	Quartile	All	0.683	0.852	.020	16	view →
UCS	DFS	Tertile	IV	0.906	0.418	.024	12	view →
UVM	DFS	Median	III,IV	0.286	0.751	.011	11	view →
READ	OS	Median	All	0.774	0.472	.037	11	view →
PCPG	OS	Median	All	0.936	1.000	.019	11	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 30 lineages.

TSSK4–HNSC (OS)

Open the HNSC breakdown →