Q-omics provides the consensus-scored TSSK1A profile across patient tissues and cancer cell-line models. TSSK1A expression is associated with patient survival in 14 of 34 cancer types, with the highest sampling consensus in KIRP. Among the 18 cancer types available for tumor–normal comparison, TSSK1A is differentially expressed in 5, with the highest sampling consensus in THCA. Additionally, TSSK1A RNA expression shows 9,735 significant gene co-expression associations, with the highest sampling consensus in ESCA. Together, these results highlight KIRP, THCA, and ESCA as cancer lineages where TSSK1A shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for TSSK1A — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes TSSK1A survival associations across molecular data types. TSSK1A RNA expression shows survival associations in the most cancer types (14). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible TSSK1A RNA expression–survival associations across cancer types. High TSSK1A expression shows unfavorable associations in COAD, but favorable associations in KIRP, LGG, PAAD, UCS and OV. The KIRP Kaplan–Meier curve shows clear separation, with the low-expression group declining faster, consistent with the favorable association (log-rank p = .002). Together, the overview and detailed table identify KIRP as the clearest survival context for TSSK1A RNA expression.
This table summarizes TSSK1A tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 5. The strongest signals are observed in THCA for RNA.
This table ranks reproducible tumor–normal expression differences for TSSK1A. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. TSSK1A shows lower tumor expression in THCA, LUAD and COAD and higher tumor expression in KIRC and LIHC. The THCA box plot shows higher TSSK1A RNA expression in normal versus tumor tissue (log2 FC = −0.609, t-test p < 0.001).
This table shows molecular features associated with TSSK1A in patient tissues and cancer cell lines. In patient samples, TSSK1A shows the broadest associations at the RNA and protein expression levels, with ESCA recurring as the lineage with the largest associated feature set.
