TSR1

Across TCGA patient cohorts, TSR1 protein abundance is significantly associated with the RNA expression of many other genes, with 17,279 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible TSR1-associated genes across cancer lineages are C1QBP, GINS1, and YWHAE. Each is linked with TSR1 in more than 9 cancer types. Because this analysis shows association rather than direction, both TSR1-to-partner and partner-to-TSR1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, TSR1 versus C1QBP in LSCC, with a Pearson correlation of 0.74.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TSR1→partner) and Y-score (partner→TSR1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	C1QBP →	+0.813	+0.366	<.001	<.001	3	10
UCEC	GINS1 →	+1.077	+0.261	<.001	<.001	3	9
COAD	YWHAE →	+0.628	+0.279	<.001	<.001	3	9
COAD	EIF5A →	+0.667	+0.250	<.001	<.001	3	9
BRCA	MELK →	+1.284	+0.267	<.001	<.001	3	9
GBM	EXO1 →	+1.052	+0.212	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 17,279 associations by consensus.

TSR1 vs C1QBP — LSCC

Explore this scatter interactively →