TSR1

Across TCGA patient cohorts, TSR1 mutation is significantly associated with the total protein of many other genes, with 21 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TSR1-associated genes across cancer lineages are ATM, INPP4B, and mTOR_pS2448. Each is linked with TSR1 in more than 2 cancer types. Because this analysis shows association rather than direction, both TSR1-to-partner and partner-to-TSR1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by TSR1-low versus TSR1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TSR1→partner) and Y-score (partner→TSR1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.364	-2.070	.020	.001	3	3
UCEC	INPP4B →	-0.248	-2.906	.026	.001	3	2
UCEC	mTOR_pS2448 →	-0.131	-2.446	.011	.018	3	2
UCEC	p27_pT198 →	+0.074	+2.000	.046	.030	3	2
UCEC	EGFR →	-0.147	-2.321	.008	.034	3	1
UCEC	eIF4G →	+0.260	+1.584	.015	.034	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 21 associations by consensus.

ATM by TSR1 expression — UCEC

Explore this box plot interactively →