TSR1

Across TCGA cell cohorts, TSR1 mutation is significantly associated with the RNA expression of many other genes, with 21 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible TSR1-associated genes across cancer lineages are SH3GL2, REG1B, and OR10W1. Each is linked with TSR1 in more than 1 cancer types. Because this analysis shows association rather than direction, both TSR1-to-partner and partner-to-TSR1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SH3GL2 grouped by TSR1-low versus TSR1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TSR1→partner) and Y-score (partner→TSR1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	SH3GL2 →	+1.390	+3.252	<.001	.009	3	1
LARGE_INTESTINE	REG1B →	+1.531	+2.933	.008	.003	3	1
LARGE_INTESTINE	OR10W1 →	+0.012	+3.240	<.001	.004	3	1
BLOOD_Leukemia	LRRC74A →	+0.017	+3.381	.005	.002	3	1
BLOOD_Leukemia	TAS2R8 →	+0.031	+2.926	<.001	.009	3	1
BLOOD_Leukemia	PIWIL1 →	+0.026	+3.675	.005	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 21 associations by consensus.

SH3GL2 by TSR1 expression — LARGE_INTESTINE

Explore this box plot interactively →