Across TCGA patient cohorts, TSPYL4 mutation is significantly associated with the total protein of many other genes, with 18 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TSPYL4-associated genes across cancer lineages are EGFR_pY1068, HSP70, and JNK2. Each is linked with TSPYL4 in more than 1 cancer types. Because this analysis shows association rather than direction, both TSPYL4-to-partner and partner-to-TSPYL4 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TSPYL4→partner) and Y-score (partner→TSPYL4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.239	-2.087	.013	.005	3	1
UCEC	HSP70 →	-0.355	-2.449	.021	.019	3	1
UCEC	JNK2 →	+0.162	+1.678	.034	.023	3	1
UCEC	Ku80 →	+0.322	+2.598	<.001	<.001	3	1
UCEC	Notch1 →	+0.184	+2.087	<.001	.005	3	1
UCEC	p38-MAPK_pT180_Y182 →	-0.443	-2.115	.010	.017	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 18 associations by consensus.

Exploration

TSPYL4 survival (RNA) · tumor vs normal (RNA) · all TSPYL4 data types