Across TCGA pan-cancer cohorts, TSPYL4 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of TSPYL4’s most consistent transcriptional readouts.
The strongest signal is observed in kidney chromophobe (KICH), where TSPYL4 RNA is repressed in tumor relative to normal tissue. In most cancer types TSPYL4 is over-expressed in tumor, although a few such as KICH and KIRC show the opposite, repressed pattern.
KICH, KIRC, and THCA are the cancer types where TSPYL4 tumor–normal differential expression is most reproducible.
RNA tumor vs normal associations by lineage
Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TSPYL4 RNA (log2); positive values indicate higher expression in tumor. p-values are from the differential-expression test.