TSPY8

Across TCGA patient cohorts, TSPY8 mutation is significantly associated with the RNA expression of many other genes, with 11 significant associations in total. LUSC shows the largest number of these associations.

The most reproducible TSPY8-associated genes across cancer lineages are RNU6-1059P, RNU6-348P, and RNA5SP501. Each is linked with TSPY8 in more than 1 cancer types. Because this analysis shows association rather than direction, both TSPY8-to-partner and partner-to-TSPY8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-1059P grouped by TSPY8-low versus TSPY8-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TSPY8→partner) and Y-score (partner→TSPY8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	RNU6-1059P →	+0.217	+7.924	<.001	.008	3	1
LUSC	RNU6-348P →	+0.203	+7.924	<.001	.008	3	1
LUSC	RNA5SP501 →	+0.196	+7.924	<.001	.008	3	1
LUSC	RNU7-87P →	+0.321	+7.924	<.001	.008	3	1
LUSC	RN7SKP298 →	+0.225	+7.924	.002	.008	3	1
LUSC	RNU4ATAC3P →	+0.176	+7.924	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

RNU6-1059P by TSPY8 expression — LUSC

Explore this box plot interactively →