TSPY2

Across TCGA patient cohorts, TSPY2 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,021 significant associations in total. TGCT shows the largest number of these associations.

The most reproducible TSPY2-associated GO terms across cancer lineages are Positive regulation of DNA repair, Regulation of cyclin-dependent protein kinase activity, and Regulation of double-strand break repair. Each is linked with TSPY2 in more than 3 cancer types. Because this analysis shows association rather than direction, both TSPY2-to-partner and partner-to-TSPY2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of DNA repair grouped by TSPY2-low versus TSPY2-high in TGCT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TSPY2→partner) and Y-score (partner→TSPY2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
TGCT	Positive regulation of DNA repair →	+0.018	+1.375	<.001	<.001	3	4
LIHC	Regulation of cyclin-dependent protein kinase activity →	+0.022	+0.336	<.001	<.001	3	4
TGCT	Regulation of double-strand break repair →	+0.019	+1.180	.003	<.001	3	3
GBM	Negative regulation of striated muscle cell differentiation →	+0.026	+0.136	<.001	.001	3	3
SKCM	IRES-dependent viral translational initiation →	+0.021	+0.183	.004	<.001	3	3
TGCT	Negative regulation of cytoplasmic translation →	+0.049	+1.420	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,021 associations by consensus.

Positive regulation of DNA repair by TSPY2 expression — TGCT

Explore this box plot interactively →