TSPOAP1

Across TCGA patient cohorts, TSPOAP1 mutation is significantly associated with the RNA expression of many other genes, with 5,725 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TSPOAP1-associated genes across cancer lineages are EMC1, RAD51, and C5orf22. Each is linked with TSPOAP1 in more than 4 cancer types. Because this analysis shows association rather than direction, both TSPOAP1-to-partner and partner-to-TSPOAP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EMC1 grouped by TSPOAP1-low versus TSPOAP1-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TSPOAP1→partner) and Y-score (partner→TSPOAP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	EMC1 →	+0.322	+1.993	.001	.002	3	5
UCEC	RAD51 →	+0.671	+1.595	<.001	<.001	3	4
LUAD	C5orf22 →	+0.663	+2.632	<.001	.005	3	4
LUAD	GUF1 →	+0.560	+3.379	<.001	.004	3	4
UCEC	CENPH →	+0.453	+1.313	<.001	.001	3	4
COAD	SKA1 →	+0.901	+4.536	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,725 associations by consensus.

EMC1 by TSPOAP1 expression — COAD

Explore this box plot interactively →