TSPOAP1

Across TCGA pan-cancer cohorts, TSPOAP1 RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of TSPOAP1’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where TSPOAP1 RNA is repressed in tumor relative to normal tissue. In most cancer types TSPOAP1 is over-expressed in tumor, although a few such as KIRC and BLCA show the opposite, repressed pattern.

KIRC, BLCA, and KICH are the cancer types where TSPOAP1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TSPOAP1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	All	II,III,IV	−0.562	<.001	11	view →
BLCA	Male	IV	−2.077	<.001	10	view →
KICH	Female	All	−1.825	<.001	9	view →
THCA	Female	II,III,IV	−0.984	<.001	9	view →
HNSC	All	All	−0.560	<.001	9	view →
LUAD	All	II,III,IV	−0.715	<.001	8	view →
LUSC	Male	All	−0.672	<.001	7	view →
UCEC	All	All	−0.886	<.001	6	view →
BRCA	Female	All	−0.747	<.001	6	view →
CHOL	Female	All	+2.533	<.001	5	view →
COAD	Female	All	+0.753	.009	3	view →
READ	All	III,IV	+0.905	.011	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

TSPOAP1–KIRC

Open the KIRC breakdown →