TSPOAP1

Across TCGA cell cohorts, TSPOAP1 mutation is significantly associated with the RNA expression of many other genes, with 881 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TSPOAP1-associated genes across cancer lineages are ANKRD54, SGSM3, and RNASEH2A. Each is linked with TSPOAP1 in more than 1 cancer types. Because this analysis shows association rather than direction, both TSPOAP1-to-partner and partner-to-TSPOAP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ANKRD54 grouped by TSPOAP1-low versus TSPOAP1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TSPOAP1→partner) and Y-score (partner→TSPOAP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	ANKRD54 →	+0.558	+2.829	<.001	<.001	3	2
LARGE_INTESTINE	SGSM3 →	+0.722	+2.743	<.001	.001	3	2
LARGE_INTESTINE	RNASEH2A →	+0.602	+2.743	.005	.001	3	2
LARGE_INTESTINE	ACBD5 →	+0.824	+2.743	<.001	.001	3	2
LARGE_INTESTINE	TRIM37 →	+0.647	+2.743	<.001	.001	3	2
LARGE_INTESTINE	OSBP →	+0.562	+2.743	.002	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 881 associations by consensus.

ANKRD54 by TSPOAP1 expression — LARGE_INTESTINE

Explore this box plot interactively →