TSPEAR-AS1

Across TCGA pan-cancer cohorts, TSPEAR-AS1 RNA is linked to patient survival in 25 of 34 cancer types, making it the most broadly survival-associated TSPEAR-AS1 data layer.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher TSPEAR-AS1 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated TSPEAR-AS1 expression acts as an unfavorable survival marker, although some lineages such as PAAD and READ show a favorable association.

KIRC, COAD, and ACC are the cancer types where TSPEAR-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	DFS	Median	All	0.550	0.696	<.001	104	view →
COAD	OS	Tertile	III,IV	0.707	0.913	<.001	57	view →
ACC	DFS	Tertile	All	0.393	0.838	.003	38	view →
PAAD	OS	Median	All	0.526	0.292	.001	37	view →
OV	OS	Tertile	All	0.792	0.910	<.001	34	view →
UVM	DFS	Tertile	II,III,IV	0.616	0.891	.003	31	view →
LUSC	DFS	Tertile	III,IV	0.484	0.786	.003	26	view →
READ	OS	Tertile	III,IV	0.638	0.271	.008	23	view →
LUAD	OS	Tertile	All	0.855	0.767	.014	16	view →
SKCM	OS	Tertile	All	0.801	0.736	.024	14	view →
STAD	OS	Median	III,IV	0.724	0.353	.008	10	view →
BRCA	OS	Quartile	II,III,IV	0.398	0.681	.014	10	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 25 lineages.

TSPEAR-AS1–KIRC (DFS)

Open the KIRC breakdown →