TSPEAR-AS1

Across TCGA pan-cancer cohorts, TSPEAR-AS1 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of TSPEAR-AS1’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where TSPEAR-AS1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types TSPEAR-AS1 is over-expressed in tumor, although a few such as BRCA and LUAD show the opposite, repressed pattern.

COAD, HNSC, and LIHC are the cancer types where TSPEAR-AS1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TSPEAR-AS1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Female	II,III,IV	+0.655	<.001	9	view →
HNSC	Male	II,III,IV	+0.748	<.001	8	view →
LIHC	Male	All	+0.671	<.001	8	view →
STAD	All	All	+0.613	.001	8	view →
BRCA	All	III,IV	−0.291	<.001	6	view →
LUAD	Male	II,III,IV	−0.873	<.001	5	view →
THCA	Male	All	−0.519	.001	5	view →
UCEC	All	All	−0.401	.024	2	view →
PRAD	All	All	−0.106	.006	2	view →
CHOL	Female	All	−0.473	.008	1	view →
KICH	Male	All	−0.138	.026	1	view →
KIRC	Male	All	+0.070	.026	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

TSPEAR-AS1–COAD

Open the COAD breakdown →