TSPAN9-IT1

Across TCGA pan-cancer cohorts, TSPAN9-IT1 RNA is linked to patient survival in 15 of 34 cancer types, making it the most broadly survival-associated TSPAN9-IT1 data layer.

The strongest signal is observed in mesothelioma (MESO), where higher TSPAN9-IT1 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated TSPAN9-IT1 expression acts as an unfavorable survival marker, although some lineages such as KIRC and ESCA show a favorable association.

MESO, UVM, and LUSC are the cancer types where TSPAN9-IT1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
MESO	OS	Tertile	IV	0.077	0.592	.019	72	view →
UVM	OS	Tertile	All	0.218	0.696	.014	36	view →
LUSC	OS	Tertile	IV	0.001	0.673	.014	36	view →
LUAD	OS	Tertile	II,III,IV	0.572	0.726	.014	36	view →
OV	OS	Quartile	III,IV	0.745	0.868	.001	34	view →
COAD	OS	Tertile	IV	0.045	0.659	<.001	27	view →
KICH	OS	Quartile	All	0.917	1.000	.021	22	view →
HNSC	DFS	Tertile	IV	0.178	0.474	.011	18	view →
TGCT	OS	Tertile	II,III,IV	0.752	1.000	.019	18	view →
SKCM	OS	Tertile	IV	0.415	0.861	.014	9	view →
PAAD	DFS	Tertile	All	0.270	0.481	.027	9	view →
STAD	DFS	Quartile	All	0.534	0.750	.014	7	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 15 lineages.

TSPAN9-IT1–MESO (OS)

Open the MESO breakdown →