TSPAN8

Across TCGA pan-cancer cohorts, TSPAN8 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated TSPAN8 data layer compared with 22 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher TSPAN8 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated TSPAN8 expression acts as an unfavorable survival marker, although some lineages such as PDAC and UCEC show a favorable association.

LUAD, PDAC, and HNSC are the cancer types where TSPAN8 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	OS	Median	II,III,IV	0.477	0.826	.004	31	view →
PDAC	OS	Median	III,IV	0.592	0.300	.004	31	view →
HNSC	OS	Median	III,IV	0.527	0.785	.007	25	view →
GBM	DFS	Quartile	All	0.211	0.489	.007	10	view →
UCEC	DFS	Quartile	All	1.000	0.788	.009	4	view →
CCRCC	OS	Median	All	0.913	0.747	.008	4	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

TSPAN8–LUAD (OS)

Open the LUAD breakdown →