TSPAN8

Across TCGA pan-cancer cohorts, TSPAN8 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of TSPAN8’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where TSPAN8 RNA is repressed in tumor relative to normal tissue. In most cancer types TSPAN8 is over-expressed in tumor, although a few such as KIRC and KICH show the opposite, repressed pattern.

KIRC, KICH, and THCA are the cancer types where TSPAN8 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TSPAN8 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	II,III,IV	−4.590	<.001	12	view →
KICH	Male	All	−6.366	<.001	11	view →
THCA	Male	IV	−2.576	<.001	11	view →
HNSC	Male	All	−1.574	<.001	8	view →
KIRP	Male	All	−3.665	<.001	7	view →
LUSC	Female	II,III,IV	−3.239	<.001	7	view →
BRCA	All	III,IV	−1.656	<.001	6	view →
LIHC	All	All	+1.583	<.001	5	view →
COAD	Female	All	−1.324	<.001	4	view →
STAD	All	All	+2.120	.008	3	view →
READ	All	II,III,IV	−1.172	.015	3	view →
BLCA	Male	All	−1.698	.025	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

TSPAN8–KIRC

Open the KIRC breakdown →