TSPAN8

Across TCGA patient cohorts, TSPAN8 RNA expression is significantly associated with the protein abundance of many other proteins, with 14,348 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible TSPAN8-associated proteins across cancer lineages are SH3BGRL2, CSE1L, and PBLD. Each is linked with TSPAN8 in more than 5 cancer types. Because this analysis shows association rather than direction, both TSPAN8-to-partner and partner-to-TSPAN8 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, TSPAN8 versus SH3BGRL2 in GBM, with a Pearson correlation of 0.46.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (TSPAN8→partner) and Y-score (partner→TSPAN8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	SH3BGRL2 →	+0.728	+0.690	<.001	<.001	3	6
LSCC	CSE1L →	-0.382	-1.323	<.001	<.001	3	5
UCEC	PBLD →	+0.640	+1.455	<.001	.004	3	5
GBM	ADD3 →	+0.406	+0.529	.002	.003	3	5
HNSC	CCDC149_S379 →	+0.525	+0.950	<.001	.004	3	5
COAD	AGR3 →	+0.806	+0.762	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 14,348 associations by consensus.

TSPAN8 vs SH3BGRL2 — GBM

Explore this scatter interactively →