TSPAN8

Across TCGA patient cohorts, TSPAN8 mutation is significantly associated with the RNA expression of many other genes, with 2,005 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TSPAN8-associated genes across cancer lineages are RN7SKP247, MTND4LP9, and SLC35G4. Each is linked with TSPAN8 in more than 2 cancer types. Because this analysis shows association rather than direction, both TSPAN8-to-partner and partner-to-TSPAN8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RN7SKP247 grouped by TSPAN8-low versus TSPAN8-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TSPAN8→partner) and Y-score (partner→TSPAN8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	RN7SKP247 →	+0.164	+4.973	.004	.009	3	3
BLCA	MTND4LP9 →	+0.214	+6.289	<.001	.001	3	2
BLCA	SLC35G4 →	+0.055	+5.177	<.001	.007	3	2
COAD	OR8J1 →	+0.074	+7.741	<.001	.009	3	2
UCEC	LRRC37A16P →	+0.737	+3.470	.001	.003	3	2
UCEC	SETD5 →	+0.619	+3.378	.002	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,005 associations by consensus.

RN7SKP247 by TSPAN8 expression — BLCA

Explore this box plot interactively →