TSPAN8

Across TCGA patient cohorts, TSPAN8 mutation is significantly associated with the total protein of many other genes, with 18 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TSPAN8-associated genes across cancer lineages are c-Met, MAPK_pT202_Y204, and PDK1_pS241. Each is linked with TSPAN8 in more than 1 cancer types. Because this analysis shows association rather than direction, both TSPAN8-to-partner and partner-to-TSPAN8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, c-Met grouped by TSPAN8-low versus TSPAN8-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TSPAN8→partner) and Y-score (partner→TSPAN8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	c-Met →	+0.182	+3.033	.007	.017	3	2
SKCM	MAPK_pT202_Y204 →	+0.487	+3.000	.018	.034	3	1
SKCM	PDK1_pS241 →	-0.202	-2.567	.008	.011	3	1
SKCM	PREX1 →	-0.322	-3.000	.033	.034	3	1
SKCM	Rb →	+0.213	+1.762	.003	.049	3	1
SKCM	Bak →	+0.301	+2.584	.003	.011	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 18 associations by consensus.

c-Met by TSPAN8 expression — SKCM

Explore this box plot interactively →