TSPAN8

Across TCGA cell cohorts, TSPAN8 mutation is significantly associated with the RNA expression of many other genes, with 24 significant associations in total. LUNG_SCLC shows the largest number of these associations.

The most reproducible TSPAN8-associated genes across cancer lineages are OR1L3, TAAR1, and LCN1. Each is linked with TSPAN8 in more than 1 cancer types. Because this analysis shows association rather than direction, both TSPAN8-to-partner and partner-to-TSPAN8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR1L3 grouped by TSPAN8-low versus TSPAN8-high in BREAST.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TSPAN8→partner) and Y-score (partner→TSPAN8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	OR1L3 →	+0.022	+5.169	<.001	.005	3	1
BLOOD_Leukemia	TAAR1 →	+0.021	+4.922	<.001	.009	3	1
BLOOD_Leukemia	LCN1 →	+0.050	+4.922	<.001	.009	3	1
BLOOD_Leukemia	SPATA31A7 →	+0.038	+5.539	<.001	.003	3	1
LARGE_INTESTINE	CDH20 →	+0.093	+3.029	.001	.003	3	1
LARGE_INTESTINE	C6orf118 →	+0.133	+4.600	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 24 associations by consensus.

OR1L3 by TSPAN8 expression — BREAST

Explore this box plot interactively →