TSPAN8

Across TCGA cell cohorts, TSPAN8 mutation is significantly associated with the mutation status of many other genes, with 1,163 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TSPAN8-associated genes across cancer lineages are HSD17B1, EP400, and ABCC4. Each is linked with TSPAN8 in more than 2 cancer types. Because this analysis shows association rather than direction, both TSPAN8-to-partner and partner-to-TSPAN8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, HSD17B1 grouped by TSPAN8-low versus TSPAN8-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TSPAN8→partner) and Y-score (partner→TSPAN8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	HSD17B1 →	+5.392	+4.824	.004	.004	1	3
BLOOD_Leukemia	EP400 →	+2.238	+4.044	.005	.005	1	3
BLOOD_Lymphoma	ABCC4 →	+4.429	+5.247	.005	.005	1	2
CNS	NKTR →	+4.459	+5.277	.005	.005	1	2
CNS	USP22 →	+4.044	+5.000	.008	.008	1	2
CNS	CYP26B1 →	+5.044	+5.614	.003	.003	1	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,163 associations by consensus.

HSD17B1 by TSPAN8 expression — SKIN

Explore this box plot interactively →