TSPAN6

Across TCGA patient cohorts, TSPAN6 total protein is significantly associated with the go_rna of many other GO terms, with 7,053 significant associations in total. LIHC shows the largest number of these associations.

The most reproducible TSPAN6-associated GO terms across cancer lineages are L-proline biosynthetic process, mRNA alternative polyadenylation, and Stress granule disassembly. Each is linked with TSPAN6 in more than 16 cancer types. Because this analysis shows association rather than direction, both TSPAN6-to-partner and partner-to-TSPAN6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, L-proline biosynthetic process grouped by TSPAN6-low versus TSPAN6-high in KICH.

total protein associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TSPAN6→partner) and Y-score (partner→TSPAN6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KICH	L-proline biosynthetic process →	+0.088	+0.316	.002	.005	3	17
ACC	mRNA alternative polyadenylation →	+0.064	+0.445	<.001	<.001	3	16
ACC	Stress granule disassembly →	+0.050	+0.368	.001	.003	3	15
THYM	Protein nitrosylation →	+0.033	+0.098	.004	.001	3	14
THYM	Regulation of the force of heart contraction →	+0.046	+0.118	.004	.004	3	14
TGCT	Cellular response to leucine starvation →	-0.062	-0.168	<.001	<.001	3	14

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,053 associations by consensus.

L-proline biosynthetic process by TSPAN6 expression — KICH

Explore this box plot interactively →