TSPAN6

Across TCGA pan-cancer cohorts, TSPAN6 RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of TSPAN6’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where TSPAN6 RNA is repressed in tumor relative to normal tissue. In most cancer types TSPAN6 is over-expressed in tumor, although a few such as KICH and KIRC show the opposite, repressed pattern.

KICH, KIRC, and LUAD are the cancer types where TSPAN6 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TSPAN6 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	Female	II,III,IV	−2.360	<.001	11	view →
KIRC	Male	II,III,IV	−0.876	<.001	11	view →
LUAD	Male	II,III,IV	+1.408	<.001	9	view →
BRCA	Female	II,III,IV	−0.901	<.001	6	view →
HNSC	All	II,III,IV	−0.785	<.001	6	view →
LIHC	Male	All	+0.639	<.001	6	view →
LUSC	Male	II,III,IV	+1.196	<.001	5	view →
CHOL	All	All	+0.894	.002	4	view →
COAD	All	All	+0.464	.005	4	view →
BLCA	All	III,IV	+1.261	.024	3	view →
KIRP	Male	All	−0.768	<.001	3	view →
THCA	Male	III,IV	−0.497	.013	3	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

TSPAN6–KICH

Open the KICH breakdown →