TSPAN6

Across TCGA patient cohorts, TSPAN6 protein abundance is significantly associated with the RNA expression of many other genes, with 13,510 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible TSPAN6-associated genes across cancer lineages are PPP1R16B, ITK, and APOL3. Each is linked with TSPAN6 in more than 5 cancer types. Because this analysis shows association rather than direction, both TSPAN6-to-partner and partner-to-TSPAN6 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, TSPAN6 versus PPP1R16B in HNSC, with a Pearson correlation of -0.31.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TSPAN6→partner) and Y-score (partner→TSPAN6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	PPP1R16B →	-0.918	-0.529	<.001	.002	3	6
LSCC	ITK →	-0.940	-0.615	<.001	<.001	3	6
COAD	APOL3 →	-0.949	-0.667	<.001	.001	3	6
LSCC	RHOH →	-0.913	-0.562	<.001	<.001	3	6
UCEC	CTLA4 →	-1.096	-0.541	<.001	<.001	3	6
COAD	PRF1 →	-1.235	-0.642	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 13,510 associations by consensus.

TSPAN6 vs PPP1R16B — HNSC

Explore this scatter interactively →