TSPAN6

Across TCGA patient cohorts, TSPAN6 mutation is significantly associated with the RNA expression of many other genes, with 611 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TSPAN6-associated genes across cancer lineages are OR4K15, RN7SL764P, and OR56B1. Each is linked with TSPAN6 in more than 1 cancer types. Because this analysis shows association rather than direction, both TSPAN6-to-partner and partner-to-TSPAN6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR4K15 grouped by TSPAN6-low versus TSPAN6-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TSPAN6→partner) and Y-score (partner→TSPAN6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	OR4K15 →	+0.063	+2.850	<.001	.002	3	2
SKCM	RN7SL764P →	+0.249	+5.436	<.001	.005	3	2
UCEC	OR56B1 →	+0.171	+1.933	<.001	.009	3	2
UCEC	RN7SKP77 →	+0.095	+3.812	<.001	.008	3	2
UCEC	PDCL3P1 →	+0.104	+1.715	.002	.007	3	2
UCEC	SRIP1 →	+0.121	+2.680	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 611 associations by consensus.

OR4K15 by TSPAN6 expression — UCEC

Explore this box plot interactively →