TSPAN6

Across TCGA cell cohorts, TSPAN6 total protein is significantly associated with the go_rna of many other GO terms, with 4,717 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible TSPAN6-associated GO terms across cancer lineages are Heme biosynthetic process, Heme metabolic process, and Porphyrin-containing compound metabolic process. Each is linked with TSPAN6 in more than 8 cancer types. Because this analysis shows association rather than direction, both TSPAN6-to-partner and partner-to-TSPAN6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Heme biosynthetic process grouped by TSPAN6-low versus TSPAN6-high in OVARY.

total protein associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TSPAN6→partner) and Y-score (partner→TSPAN6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	Heme biosynthetic process →	-0.090	-0.516	.002	.009	3	9
LUNG_NSCLC_LUAD	Heme metabolic process →	-0.073	-0.263	.001	.039	3	9
OVARY	Porphyrin-containing compound metabolic process →	-0.074	-0.460	.009	.007	3	8
STOMACH	Porphyrin-containing compound biosynthetic process →	-0.093	-0.506	.017	.036	3	8
URINARY_TRACT	Adult walking behavior →	-1.042	-0.433	.030	.015	3	8
LUNG_SCLC	Tetrapyrrole metabolic process →	-0.076	-0.521	.006	.005	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,717 associations by consensus.

Heme biosynthetic process by TSPAN6 expression — OVARY

Explore this box plot interactively →